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The University of Pennsylvania has a long and storied history dating back to its earliest origins in colonial Philadelphia in Over the following century and a half, Penn would dramatically expand and restructure into the organization that has become familiar to us today. Chemistry did not begin at Penn as an independent field. Instead, the discipline fell under several umbrellas before emerging as a natural sciences department. In , the Medical School was established by John Morgan.

One of the first faculty of this new school was Benjamin Rush, the only signer of the Declaration of Independence to hold a medical degree. Rush was appointed Professor of Chemistry at the College in This subdivision of the Medical School would later evolve into the Department of Biochemistry and Biophysics. Coinciding with this move was another restructuring which would result in the formation of the Department of Science later renamed as the Towne Scientific School. Among the first appointments in this school was noted German chemist Frederick A.